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202 Firstly, DNA methylation regulates different insulin signaling genes, such as insulin ( INS ), insulin receptor substrate 1 ( IRS1 ), Insulin-like growth factor-1/2 (IGF-1/2), Insulin-like growth factor-binding protein 1/2 (IGFBP-1/2), phosphatidylinositol 3-kinase regulatory subunit (PIK3R1), and Glucagon-like peptide-1 receptor (GLP-1R)

doi: 10.1089/gtmb.2015.0291 37 NewgardCBAnJBainJRMuehlbauerMJStevensRDLienLFet al

Joshua A Huber Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, United States Contribution JAH, Acquisition of data, Analysis and interpretation of data Competing interests The authors declare that no competing interests exist