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Adenomatous changes were defined as (capsulated and compressed nodules composed of cystically dilated follicles, lined by bland cells with no or little atypia, intraluminal papillae might be present) and were scored as absent or present only
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HPLC methods with either UV or fluorescence detection require derivatisation of GSH prior to detection which causes further limitations driven principally as a result of enhanced susceptibility to GSH degradation and auto oxidation, instability of derivatised GSH adduct and suboptimal derivatisation conditions
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