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Doctors weigh in

Important safety considerations include risk of thyroid C-cell tumors (contraindicated in MEN2 or personal/family history of medullary thyroid carcinoma), pancreatitis, gallbladder disease, hypoglycemia when used with insulin or secretagogues, and potential worsening of diabetic retinopathy in some patients

semaglutide, dulaglutide, and tirzepatide each come with patient safety warnings to speak with a doctor before starting treatment if they have DR

Researchers interested in experimentation with semaglutide may wish to review the risks associated with online purchases of semaglutide: Counterfeit products: Any company can sell a vial of powder and label it as semaglutide