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Convincing data with sufficient power to detect the risk/benefit profile of their use remain to be illustrated

These findings suggest that glucagon functions as a dynamic modulator of mitochondrial activity, and this regulatory axis remains functional during the early stages of metabolic disease

The more cautious interpretation is that patients who receive GLP-1 receptor agonists may differ in important but incompletely measured ways from those treated with insulin or metformin, including overall health, treatment access, healthcare follow-up, or cardiometabolic care intensity

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